Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.

The Journal of experimental medicine - 14 Nov 2016

Zamora-Pineda Jesus, Kumar Ashok, Suh Jung H, Zhang Meng, Saba Julie D

Abstract excerpt

T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)-mediated metabolism. Although SPL is robustly expressed in thymic epithelial cells (TECs), in this study, we show that deleting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Aldehyde-Lyases
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Space

Share to Hematopoiesis

Share to Lysophospholipids

Share to Sphingosine

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 27810923
DOI: 10.1084/jem.20160287
PMCID: PMC5110016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.PMID 27810923Read ↗

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.Semantic proximity Read ↗

Metabolic Regulation of Thymic Epithelial Cell Function.Semantic proximity Read ↗

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.Semantic proximity Read ↗

Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype.Semantic proximity Read ↗

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus.Semantic proximity Read ↗

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist.Semantic proximity Read ↗

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.Semantic proximity Read ↗

Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated MiceSemantic proximity Read ↗

Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery.Semantic proximity Read ↗

Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.