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The Lysosome as a Regulatory Hub

8 Aug 2016

Abstract excerpt

The lysosome has long been viewed as the recycling center of the cell. However, recent discoveries have challenged this simple view and have established a central role of the lysosome in nutrient-dependent signal transduction. The degradative role of the lysosome and its newly discovered signaling functions are not in conflict but rather cooperate extensively to mediate fundamental cellular activities such as...

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PMID: 27501449
DOI: 10.1146/annurev-cellbio-111315-125125

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