Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2016

Vermeren Sonja, Miles Katherine, Chu Julia Y, Salter Donald, Zamoyska Rose, Gray Mohini

Abstract excerpt

Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although PTPN22 is most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Antibody Complex
Share to Arthritis, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Degranulation

Share to Neutrophil Activation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptors, IgG

Share to src-Family Kinases

Share to Syk Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 27807193
DOI: 10.4049/jimmunol.1600604
PMCID: PMC5136470

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.PMID 27807193Read ↗

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals.Semantic proximity Read ↗

The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis.Semantic proximity Read ↗

Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.Semantic proximity Read ↗

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.Semantic proximity Read ↗

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis.Semantic proximity Read ↗

Loss of PTPN22 Promotes Intestinal Inflammation by Compromising Granulocyte-mediated Antibacterial Defence.Semantic proximity Read ↗

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.Semantic proximity Read ↗

Regulation of T Cell Signaling and Immune Responses by PTPN22.Semantic proximity Read ↗

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.Semantic proximity Read ↗

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.Semantic proximity Read ↗

The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.