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Article

Loss of PTPN22 Promotes Intestinal Inflammation by Compromising Granulocyte-mediated Antibacterial Defence.

Journal of Crohn's & colitis - 18 Dec 2021

Spalinger Marianne R, Schwarzfischer Marlene, Niechcial Anna, Atrott Kirstin, Laimbacher Andrea, Gottier Claudia, Lang Silvia, Scharl Michael

Abstract excerpt

BACKGROUND AND AIMS: A single nucleotide polymorphism in protein tyrosine phosphatase non-receptor type 22 [PTPN22] has been associated with the onset of autoimmune disorders, but protects from Crohn's disease. PTPN22 deficiency in mice promotes intestinal inflammation by modulating lymphocyte function. However, the impact of myeloid PTPN22 in colitis development remains unclear. The aim of this study was to...

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Identifiers

PMID: 34089589
DOI: 10.1093/ecco-jcc/jjab098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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