The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis.

doi:10.1016/j.freeradbiomed.2024.12.046

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Article

The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis.

Free radical biology & medicine - 16 Feb 2025

Gardette Anaïs, Marzaioli Viviana, Bedouhene Samia, Hayem Gilles, Hurtado-Nedelec Margarita, He Yantao, Dang Pham My-Chan, Dieudé Philippe, Zhang Zhong-Yin, Marie Jean-Claude, El-Benna Jamel

Abstract excerpt

Neutrophils are essential for host defense against infections, but they also play a key role in acute and chronic inflammation. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes the lymphoid-specific tyrosine phosphatase (Lyp) and a genetic single-nucleotide polymorphism of PTPN22 rs2476601 (R620W) has been associated with several human autoimmune diseases, including rheumatoid arthritis...

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Identifiers

PMID: 39724988
DOI: 10.1016/j.freeradbiomed.2024.12.046
PMCID: PMC12990828

Genes

PTPN22

Variants

rs2476601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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