Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF1R signaling in perinatal mesenchymal stem cells determines definitive hematopoiesis in bone marrow

22 Oct 2024

Abstract excerpt

ABTRACT: During the transition from embryonic to adult life, the sites of hematopoiesis undergo dynamic shifts across various tissues. In adults, although bone marrow (BM) becomes the primary site for definitive hematopoiesis, the establishment of the BM niche for accommodating hematopoietic stem cells (HSCs) remains incompletely understood. Here, we reveal that perinatal BM mesenchymal stem cells (BMSCs) exhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematological disorders and diagnostics
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39437540
DOI: 10.1182/blood.2024024258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF1R signaling in perinatal mesenchymal stem cells determines definitive hematopoiesis in bone marrowPMID 39437540Read ↗

TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone MarrowSemantic proximity Read ↗

The evolving hematopoietic niche during developmentSemantic proximity Read ↗

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.Semantic proximity Read ↗

Regional specialization and fate specification of bone stromal cells in skeletal developmentSemantic proximity Read ↗

Mds1CreERT2, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells.Semantic proximity Read ↗

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewalSemantic proximity Read ↗

Fetal liver hematopoiesis: from development to deliverySemantic proximity Read ↗

Transcriptome Analysis in Prenatal IGF1-Deficient Mice Identifies Molecular Pathways and Target Genes Involved in Distal Lung DifferentiationSemantic proximity Read ↗

Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic ApplicationsSemantic proximity Read ↗

Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cellsSemantic proximity Read ↗

Bone marrow mesenchymal stem cells of the intrauterine growth-restricted rat offspring exhibit enhanced adipogenic phenotype.Semantic proximity Read ↗

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic nicheSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.