Article
Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.
Human molecular genetics - 1 Jul 2000
Blagitko N, Mergenthaler S, Schulz U, Wollmann H A, Craigen W, Eggermann T, Ropers H H, Kalscheuer V M
Abstract excerpt
As part of a systematic screen for novel imprinted genes of human chromosome 7 we have investigated GRB10, which belongs to a small family of adapter proteins, known to interact with a number of receptor tyrosine kinases and signalling molecules. Upon allele-specific transcription analysis involving multiple distinct splice variants in various fetal tissues, we found that human GRB10 is imprinted in a highly...
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