Article
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).
Haematologica - 1 Aug 2008
Liso Arcangelo, Castiglione Filippo, Cappuccio Antonio, Stracci Fabrizio, Schlenk Richard F, Amadori Sergio, Thiede Christian, Schnittger Susanne, Valk Peter J M, Döhner Konstanze, Martelli Massimo F, Schaich Markus, Krauter Jürgen, Ganser Arnold, Martelli Maria P, Bolli Niccolò, Löwenberg Bob, Haferlach Torsten, Ehninger Gerhard, Mandelli Franco, Döhner Hartmut, Michor Franziska, Falini Brunangelo
Abstract excerpt
Acute myeloid leukemia with mutated NPM1 gene and aberrant cytoplasmic expression of nucleophosmin (NPMc(+) acute myeloid leukemia) shows distinctive biological and clinical features. Experimental evidence of the oncogenic potential of the nucleophosmin mutant is, however, still lacking, and it is unclear whether other genetic lesion(s), e.g. FLT3 internal tandem duplication, cooperate with NPM1 mutations in...
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