Article
MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.
Molecular cell - 3 Sept 2015
Chen Hongshan, Ruiz Penelope D, McKimpson Wendy M, Novikov Leonid, Kitsis Richard N, Gamble Matthew J
Abstract excerpt
Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism typified by stable proliferative arrest, a persistent DNA damage response, and the senescence-associated secretory phenotype (SASP), which helps to maintain the senescent state and triggers bystander senescence in a paracrine fashion. Here, we demonstrate that the tumor suppressive histone variant macroH2A1 is a critical component of the positive...
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