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Article

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A.

The Journal of general physiology - 1 Nov 2016

Lim Novandy K, Lam Andy K M, Dutzler Raimund

Abstract excerpt

The TMEM16 proteins constitute a family of membrane proteins with unusual functional breadth, including lipid scramblases and Cl- channels. Members of both these branches are activated by Ca2+, acting from the intracellular side, and probably share a common architecture, which was defined in the recent structure of the lipid scramblase nhTMEM16. The structural features of subunits and the arrangement of...

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Identifiers

PMID: 27799318
DOI: 10.1085/jgp.201611650
PMCID: PMC5089934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A.PMID 27799318Read ↗

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