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Article

Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A).

Scientific reports - 20 Apr 2020

Segura-Covarrubias Guadalupe, Aréchiga-Figueroa Iván A, De Jesús-Pérez José J, Sánchez-Solano Alfredo, Pérez-Cornejo Patricia, Arreola Jorge

Abstract excerpt

Anoctamin-1 (ANO1 or TMEM16A) is a homo-dimeric Ca2+-activated Cl- channel responsible for essential physiological processes. Each monomer harbours a pore and a Ca2+-binding pocket; the voltage-dependent binding of two intracellular Ca2+ ions to the pocket gates the pore. However, in the absence of intracellular Ca2+ voltage activates TMEM16A by an unknown mechanism. Here we show voltage-activated anion currents...

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Identifiers

PMID: 32313203
DOI: 10.1038/s41598-020-62860-9
PMCID: PMC7170896

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A).PMID 32313203Read ↗

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