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Article

Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels.

PloS one - 1 Jan 2017

Pifferi Simone

Abstract excerpt

TMEM16A and TMEM16B encode for Ca2+-activated Cl- channels (CaCC) and are expressed in many cell types and play a relevant role in many physiological processes. Here, I performed a site-directed mutagenesis study to understand the molecular mechanisms of ion permeation of TMEM16B. I mutated two positive charged residues R573 and K540, respectively located at the entrance and inside the putative channel pore and I...

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Identifiers

PMID: 28046119
DOI: 10.1371/journal.pone.0169572
PMCID: PMC5207786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels.PMID 28046119Read ↗

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