Article
Detection of CYP2C19 Genetic Variants in Malaysian Orang Asli from Massively Parallel Sequencing Data.
PloS one - 1 Jan 2016
Ang Geik Yong, Yu Choo Yee, Subramaniam Vinothini, Abdul Khalid Mohd Ikhmal Hanif, Tuan Abdu Aziz Tuan Azlin, Johari James Richard, Ahmad Aminuddin, Abdul Rahman Thuhairah, Mohd Nor Fadzilah, Ismail Adzrool Idzwan, Md Isa Kamarudzaman, Salleh Hood, Teh Lay Kek, Salleh Mohd Zaki
Abstract excerpt
The human cytochrome P450 (CYP) is a superfamily of enzymes that have been a focus in research for decades due to their prominent role in drug metabolism. CYP2C is one of the major subfamilies which metabolize more than 10% of all clinically used drugs. In the context of CYP2C19, several key genetic variations that alter the enzyme's activity have been identified and catalogued in the CYP allele nomenclature...
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