Systematic characterization and comparison of the CYP2C9 variability of the Orang Asli in Malaysia with 12 populations.

doi:10.1016/j.dmpk.2016.04.004

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Article

Systematic characterization and comparison of the CYP2C9 variability of the Orang Asli in Malaysia with 12 populations.

Drug metabolism and pharmacokinetics - 1 Aug 2016

Teh Lay Kek, Subramaniam Vinothini, Tuan Abdu Aziz Tuan Azlin, Lee Lian Shien, Ismail Mohamed Izwan, Yu Choo Yee, Ang Geik Yong, James Johari Richard, Ismet Rose Iszati, Sahak Noor Saadah, Ahmad Aminuddin, Rahman Thuhairah Abdul, Nor Ghazali Fadzilah Mohd, Shaari SyahrulAzlin, Omar Mustaffa, Ismail Adzrool Idzwan, Md Isa Kamarudzaman, Salleh Hood, Salleh Mohd Zaki

Abstract excerpt

We conducted a systematic characterization of CYP2C9 variants in 61 Orang Asli and 96 Singaporean Malays using the whole genome sequences data and compared the variants with the other 11 HapMap populations. The frequency of rs1057910 (CYP2C9*3) is the highest in the Orang Asli compared to other populations. Three alleles with clinical implication were detected in the Orang Asli while 2 were found in the...

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PMID: 27325019
DOI: 10.1016/j.dmpk.2016.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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