Article
Inference of the Genetic Polymorphisms of CYP2D6 in Six Subtribes of the Malaysian Orang Asli from Whole-Genome Sequencing Data.
Genetic testing and molecular biomarkers - 1 Jul 2017
Yu Choo Yee, Ang Geik Yong, Subramaniam Vinothini, Johari James Richard, Ahmad Aminuddin, Abdul Rahman Thuhairah, Mohd Nor Fadzilah, Shaari Syahrul Azlin, Teh Lay Kek, Salleh Mohd Zaki
Abstract excerpt
AIMS: CYP2D6 is one of the major enzymes in the cytochrome P450 monooxygenase system. It metabolizes ∼25% of prescribed drugs and hence, the genetic diversity of a CYP2D6 gene has continued to be of great interest to the medical and pharmaceutical industries. This study was designed to perform a systematic analysis of the CYP2D6 gene in six subtribes of the Malaysian Orang Asli. METHODS: Genomic DNAs were...
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