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Article

Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway.

International journal of molecular sciences - 17 Apr 2023

Harwood Stephen J, Smith Christopher R, Lawson J David, Ketcham John M

Abstract excerpt

Within the MAPK/RAS pathway, there exists a plethora of protein-protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with KRAS-mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37108538
DOI: 10.3390/ijms24087373
PMCID: PMC10139024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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