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Article

The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function.

International journal of molecular sciences - 14 Nov 2019

Abdelkarim Hazem, Banerjee Avik, Grudzien Patrick, Leschinsky Nicholas, Abushaer Mahmoud, Gaponenko Vadim

Abstract excerpt

The flexible C-terminal hypervariable region distinguishes K-Ras4B, an important proto-oncogenic GTPase, from other Ras GTPases. This unique lysine-rich portion of the protein harbors sites for post-translational modification, including cysteine prenylation, carboxymethylation, phosphorylation, and likely many others. The functions of the hypervariable region are diverse, ranging from anchoring K-Ras4B at the...

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Identifiers

PMID: 31739603
DOI: 10.3390/ijms20225718
PMCID: PMC6888304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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