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Article

Small-molecule modulation of Ras signaling.

Nature chemical biology - 1 Aug 2014

Spiegel Jochen, Cromm Philipp M, Zimmermann Gunther, Grossmann Tom N, Waldmann Herbert

Abstract excerpt

Despite intense efforts in pharmaceutical industry and academia, a therapeutic grip on oncogenic Ras proteins has remained elusive. Mutated Ras is associated with ~20-30% of all human cancers often not responsive to established therapies. In particular, K-Ras, the most frequently mutated Ras isoform, is considered one of the most important but 'undruggable' targets in cancer research. Recently, new cavities on...

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PMID: 24929527
DOI: 10.1038/nchembio.1560

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