Article
Altered biochemical specificity of G-quadruplexes with mutated tetrads.
Nucleic acids research - 15 Dec 2016
Švehlová Kateřina, Lawrence Michael S, Bednárová Lucie, Curtis Edward A
Abstract excerpt
A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can often be restored by a second mutation that replaces the original base pair with an isosteric variant. Such concerted changes are a way to identify helical regions in secondary structures and to identify new functional motifs in sequenced genomes. In principle,...
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