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Article

Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank.

The Journal of clinical endocrinology and metabolism - 18 Jan 2024

Jensen Christian Zinck, Isaksen Jonas Lynggaard, Ahlberg Gustav, Olesen Morten Salling, Nygaard Birte, Ellervik Christina, Kanters Jørgen Kim

Abstract excerpt

CONTEXT: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. OBJECTIVE: We investigated, as previously hypothesized, if single-nucleotide variations (SNVs; formerly single-nucleotide polymorphisms) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the deiodinase 2 gene (DIO2), or rs17606253 in the...

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Share to Biological Specimen Banks
Share to Cross-Sectional Studies
Share to Hypothyroidism
Share to Iodide Peroxidase
Share to Iodothyronine Deiodinase Type II
Share to Polymorphism, Single Nucleotide
Share to Thyroxine
Share to UK Biobank

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Identifiers

PMID: 37740545
DOI: 10.1210/clinem/dgad556

Genes

DIO2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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