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Article

Senescence‐associated <scp>DNA</scp> methylation is stochastically acquired in subpopulations of mesenchymal stem cells

26 Oct 2016

Abstract excerpt

Summary Replicative senescence has a major impact on function and integrity of cell preparations. This process is reflected by continuous DNA methylation ( DNA m) changes at specific CpG dinucleotides in the course of in vitro culture, and such modifications can be used to estimate the state of cellular senescence for quality control of cell preparations. Still, it is unclear how senescence‐associated DNA m...

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Share to Epigenetics and DNA Methylation
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PMID: 27785870
DOI: 10.1111/acel.12544

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