Article
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.
Genome biology - 17 Sept 2015
Lowe Robert, Overhoff Marita G, Ramagopalan Sreeram V, Garbe James C, Koh James, Stampfer Martha R, Beach David H, Rakyan Vardhman K, Bishop Cleo L
Abstract excerpt
BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of actively dividing and deeply senescent normal human epithelial cells. RESULTS: We identify senescence-associated differentially methylated positions (senDMPs) from multiple experiments using...
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