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Article

Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence.

Stem cell research - 1 Nov 2013

Ren Jiaqiang, Stroncek David F, Zhao Yingdong, Jin Ping, Castiello Luciano, Civini Sara, Wang Huan, Feng Ji, Tran Katherine, Kuznetsov Sergei A, Robey Pamela G, Sabatino Marianna

Abstract excerpt

The outcomes of clinical trials using bone marrow stromal cell (BMSC) are variable; the degree of the expansion of BMSCs during clinical manufacturing may contribute to this variability since cell expansion is limited by senescence. Human BMSCs from aspirates of healthy subjects were subcultured serially until cell growth stopped. Phenotype and functional measurements of BMSCs from two subjects including...

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Identifiers

PMID: 23959330
DOI: 10.1016/j.scr.2013.07.005
PMCID: PMC3818332

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