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Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

5 Mar 2020

Abstract excerpt

BACKGROUND: The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem cells (iPSCs) may circumvent these limitations, and such iPSC-derived MSCs (iMSCs) are already tested in clinical trials. So far, a comparison of MSCs and iMSCs was particularly addressed in bulk...

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PMID: 32138773
DOI: 10.1186/s13287-020-01619-5

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