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Article

Epigenetic Classification of Human Mesenchymal Stromal Cells

1 Feb 2016

Abstract excerpt

Standardization of mesenchymal stromal cells (MSCs) is hampered by the lack of a precise definition for these cell preparations; for example, there are no molecular markers to discern MSCs and fibroblasts. In this study, we followed the hypothesis that specific DNA methylation (DNAm) patterns can assist classification of MSCs. We utilized 190 DNAm profiles to address the impact of tissue of origin, donor age,...

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PMID: 26862701
DOI: 10.1016/j.stemcr.2016.01.003

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