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Placental mesenchymal stem cells of fetal origin deposit epigenetic alterations during long-term culture under serum-free condition

18 Sept 2014

Abstract excerpt

OBJECTIVE: Fetal placental mesenchymal stem cells (fPMSCs) have shown promising cell therapy potentials. However, their genetic and epigenetic stability during in vitro propagation has not been well studied. We thus interrogated the methylation alterations and tumorigenicity of fPMSCs after in vitro expansion using serum-free medium. RESEARCH DESIGN AND METHODS: The properties of fPMSCs cultured in a serum-free...

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PMID: 25231124
DOI: 10.1517/14712598.2015.960837

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