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DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells

6 Nov 2009

Abstract excerpt

Within 2-3 months of in vitro culture-expansion, mesenchymal stromal cells (MSC) undergo replicative senescence characterized by cell enlargement, loss of differentiation potential and ultimate growth arrest. In this study, we have analyzed DNA methylation changes upon long-term culture of MSC by using the HumanMethylation27 BeadChip microarray assessing 27,578 unique CpG sites. Furthermore, we have compared MSC...

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PMID: 19895632
DOI: 10.1111/j.1474-9726.2009.00535.x

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