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Article

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks.

Aging - 1 Sept 2011

Schellenberg Anne, Lin Qiong, Schüler Herdit, Koch Carmen M, Joussen Sylvia, Denecke Bernd, Walenda Gudrun, Pallua Norbert, Suschek Christoph V, Zenke Martin, Wagner Wolfga

Abstract excerpt

Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colony-forming unit (CFU-f) frequency and the differentiation potential of MSC declined significantly. Relevant chromosomal aberrations were not detected by karyotyping and SNP-microarrays....

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Identifiers

PMID: 22025769
DOI: 10.18632/aging.100391
PMCID: PMC3227452

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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