Article
Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase.
Acta crystallographica. Section D, Biological crystallography - 1 Oct 2013
Pica Andrea, Merlino Antonello, Buell Alexander K, Knowles Tuomas P J, Pizzo Elio, D'Alessio Giuseppe, Sica Filomena, Mazzarella Lelio
Abstract excerpt
The deletion of five residues in the loop connecting the N-terminal helix to the core of monomeric human pancreatic ribonuclease leads to the formation of an enzymatically active domain-swapped dimer (desHP). The crystal structure of desHP reveals the generation of an intriguing fibril-like aggregate of desHP molecules that extends along the c crystallographic axis. Dimers are formed by three-dimensional domain...
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