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Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease.

Biochimie - 1 May 2012

Merlino Antonello, Picone Delia, Ercole Carmine, Balsamo Anna, Sica Filomena

Abstract excerpt

3D domain swapping is the process by which two or more protein molecules exchange part of their structure to form intertwined dimers or higher oligomers. Bovine pancreatic ribonuclease (RNase A) is able to swap the N-terminal α-helix (residues 1-13) and/or the C-terminal β-strand (residues 116-124), thus forming a variety of oligomers, including two different dimers. Cis-trans isomerization of the Asn113-Pro114...

Topics

Animals
Cattle
Dimerization
Magnetic Resonance Spectroscopy
Mutation
Protein Folding
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Ribonuclease, Pancreatic
X-Ray Diffraction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22273774
DOI: 10.1016/j.biochi.2012.01.010

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