Article
Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A.
Protein science : a publication of the Protein Society - 1 Oct 2011
Miller Katherine H, Marqusee Susan
Abstract excerpt
Domain swapping is a type of oligomerization in which monomeric proteins exchange a structural element, resulting in oligomers whose subunits recapitulate the native, monomeric fold. It has been implicated as a potential mechanism for protein aggregation, which provides a strong impetus to understand the structural determinants and folding mechanisms that trigger domain swapping. Bovine pancreatic ribonuclease A...
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