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Article

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.

Nature communications - 24 Oct 2016

Grampp Steffen, Platt James L, Lauer Victoria, Salama Rafik, Kranz Franziska, Neumann Viviana K, Wach Sven, Stöhr Christine, Hartmann Arndt, Eckardt Kai-Uwe, Ratcliffe Peter J, Mole David R, Schödel Johannes

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide association study on renal cancer susceptibility identified single-nucleotide polymorphisms (SNPs) in an intergenic region...

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Topics

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Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Chromosomes, Human, Pair 8

Share to DNA, Intergenic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Proto-Oncogene Proteins c-myc

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 27774982
DOI: 10.1038/ncomms13183
PMCID: PMC5079059

Genes

MYC
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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