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Article

MicroRNA target site polymorphisms in the VHL-HIF1α pathway predict renal cell carcinoma risk.

Molecular carcinogenesis - 1 Jan 2014

Wei Hua, Ke Hung-Lung, Lin Jie, Shete Sanjay, Wood Christopher G, Hildebrandt Michelle A T

Abstract excerpt

Renal cell carcinoma (RCC) accounts for ∼4% of all human malignancies and is the 9th leading cause of male cancer death in the United States. The purpose of this study was to determine the effect of variation within microRNA (miRNA)-binding sites of genes in the VHL-HIF1α pathway on RCC risk. We identified 429 miRNA-binding site single-nucleotide polymorphisms (SNPs) in 102 pathway genes and assessed 53...

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Share to Binding Sites
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kidney Neoplasms

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22517515
DOI: 10.1002/mc.21917
PMCID: PMC3424388

Genes

VHL
CDCP1
MAPK1
TFRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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