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Article

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer.

Scientific reports - 10 Dec 2019

Schmid Virginia, Lafleur Veronique N, Lombardi Olivia, Li Ran, Salama Rafik, Colli Leandro, Choudhry Hani, Chanock Stephen, Ratcliffe Peter J, Mole David R

Abstract excerpt

Emerging evidence suggests that dysregulation of oncogenic pathways requires precise tuning in order for cancer to develop. To test this, we examined the overlap between cis-acting elements of the hypoxia-inducible factor (HIF) pathway and cancer-susceptibility polymorphisms as defined in genome-wide association studies (GWAS). In renal cancer, where HIF is constitutively and un-physiologically activated by...

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Identifiers

PMID: 31822727
DOI: 10.1038/s41598-019-55098-7
PMCID: PMC6904466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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