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Article

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Nature genetics - 11 Mar 2012

Schödel Johannes, Bardella Chiara, Sciesielski Lina K, Brown Jill M, Pugh Chris W, Buckle Veronica, Tomlinson Ian P, Ratcliffe Peter J, Mole David R

Abstract excerpt

Although genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic polymorphisms. Here, we show that polymorphism at a remote intergenic region on chromosome 11q13.3, recently identified as a susceptibility locus for renal cell carcinoma, modulates the binding and function of...

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Share to Cell Cycle Checkpoints
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Cyclin D1

Share to Enhancer Elements, Genetic

Share to Hypoxia-Inducible Factor 1

Share to Kidney Neoplasms

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22406644
DOI: 10.1038/ng.2204
PMCID: PMC3378637

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.PMID 22406644Read ↗

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