Article
Human leucocyte antigen class I and II imputation in a multiracial population.
International journal of immunogenetics - 1 Dec 2016
Kuniholm M H, Xie X, Anastos K, Xue X, Reimers L, French A L, Gange S J, Kassaye S G, Kovacs A, Wang T, Aouizerat B E, Strickler H D
Abstract excerpt
Human leucocyte antigen (HLA) genes play a central role in response to pathogens and in autoimmunity. Research to understand the effects of HLA genes on health has been limited because HLA genotyping protocols are labour intensive and expensive. Recently, algorithms to impute HLA genotype data using genome-wide association study (GWAS) data have been published. However, imputation accuracy for most of these...
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