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Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression

20 Oct 2016

Abstract excerpt

We introduce the Microenvironment Cell Populations-counter (MCP-counter) method, which allows the robust quantification of the absolute abundance of eight immune and two stromal cell populations in heterogeneous tissues from transcriptomic data. We present in vitro mRNA mixture and ex vivo immunohistochemical data that quantitatively support the validity of our method's estimates. Additionally, we demonstrate...

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PMID: 27765066
DOI: 10.1186/s13059-016-1070-5

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