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Article

Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.

PloS one - 1 Jan 2011

Gong Inna Y, Schwarz Ute I, Crown Natalie, Dresser George K, Lazo-Langner Alejandro, Zou GuangYong, Roden Dan M, Stein C Michael, Rodger Marc, Wells Philip S, Kim Richard B, Tirona Rommel G

Abstract excerpt

Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S-warfarin plasma levels and international normalized ratio were obtained to serve as inputs to a...

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Source

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Identifiers

PMID: 22114699
DOI: 10.1371/journal.pone.0027808
PMCID: PMC3218053

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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