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Article

Exploring the complex relationship between vitamin K, gut microbiota, and warfarin variability in cardiac surgery patients.

International journal of surgery (London, England) - 1 Dec 2023

Xue Ling, Singla Rajeev K, Qin Qiong, Ding Yinglong, Liu Linsheng, Ding Xiaoliang, Qu Wenhao, Huang Chenrong, Shen Zhenya, Shen Bairong, Miao Liyan

Abstract excerpt

BACKGROUND AND OBJECTIVES: Due to the high individual variability of anticoagulant warfarin, this study aimed to investigate the effects of vitamin K concentration and gut microbiota on individual variability of warfarin in 246 cardiac surgery patients. METHODS: The pharmacokinetics and pharmacodynamics (PKPD) model predicted international normalized ratio (INR) and warfarin concentration. Serum and fecal samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37598356
DOI: 10.1097/JS9.0000000000000673
PMCID: PMC10720796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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