Article
Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms.
The pharmacogenomics journal - 1 Dec 2017
Kubo K, Ohara M, Tachikawa M, Cavallari L H, Lee M T M, Wen M S, Scordo M G, Nutescu E A, Perera M A, Miyajima A, Kaneko N, Pengo V, Padrini R, Chen Y T, Takahashi H
Abstract excerpt
Using population pharmacokinetic analysis (PPK), we attempted to identify predictors of S-warfarin clearance (CL(S)) and to clarify population differences in S-warfarin pharmacokinetics among a cohort of 378 African American, Asian and white patients. Significant predictors of CL(S) included clinical (age, body weight and sex) and genotypic (CYP2C9*2,*3 and *8) factors, as well as African American ethnicity, the...
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