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Article

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.

British journal of clinical pharmacology - 1 Jan 2012

Lane Steven, Al-Zubiedi Sameh, Hatch Ellen, Matthews Ivan, Jorgensen Andrea L, Deloukas Panos, Daly Ann K, Park B Kevin, Aarons Leon, Ogungbenro Kayode, Kamali Farhad, Hughes Dyfrig, Pirmohamed Munir

Abstract excerpt

BACKGROUND: Warfarin is a drug with a narrow therapeutic index and large interindividual variability in daily dosing requirements. Patients commencing warfarin treatment are at risk of bleeding due to excessive anticoagulation caused by overdosing. The interindividual variability in dose requirements is influenced by a number of factors, including polymorphisms in genes mediating warfarin pharmacology,...

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Identifiers

PMID: 21692828
DOI: 10.1111/j.1365-2125.2011.04051.x
PMCID: PMC3248257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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