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Article

The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.

Developmental cell - 1 May 2003

Marston Adele L, Lee Brian H, Amon Angelika

Abstract excerpt

During meiosis, DNA replication is followed by two consecutive rounds of chromosome segregation. Cells lacking the protein phosphatase CDC14 or its regulators, SPO12 and SLK19, undergo only a single meiotic division, with some chromosomes segregating reductionally and others equationally. We find that this abnormal chromosome behavior is due to an uncoupling of meiotic events. Anaphase I spindle disassembly is...

Topics

Anaphase
Cell Cycle Proteins
Cell Nucleolus
Chromatids
Chromosome Segregation
Fungal Proteins
Meiosis
Microtubule-Associated Proteins
Mutation
Nuclear Proteins
Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Time Factors

Source

Identifiers

PMID: 12737806
DOI: 10.1016/s1534-5807(03)00130-8

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The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.PMID 12737806Read ↗

Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.Semantic proximity Read ↗

Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.Semantic proximity Read ↗

FEAR but not MEN genes are required for exit from meiosis I.Semantic proximity Read ↗

Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms.Semantic proximity Read ↗

Regulation of Spo12 phosphorylation and its essential role in the FEAR network.Semantic proximity Read ↗

Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase.Semantic proximity Read ↗

Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.Semantic proximity Read ↗

Spo76p is a conserved chromosome morphogenesis protein that links the mitotic and meiotic programs.Semantic proximity Read ↗

The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.Semantic proximity Read ↗

Slk19p is necessary to prevent separation of sister chromatids in meiosis I.Semantic proximity Read ↗

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.Semantic proximity Read ↗

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