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Article

Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.

Cancer research - 1 Dec 2016

Lu Songjian, Cai Chunhui, Yan Gonghong, Zhou Zhuan, Wan Yong, Chen Vicky, Chen Lujia, Cooper Gregory F, Obeid Lina M, Hannun Yusuf A, Lee Adrian V, Lu Xinghua

Abstract excerpt

Defining processes that are synthetic lethal with p53 mutations in cancer cells may reveal possible therapeutic strategies. In this study, we report the development of a signal-oriented computational framework for cancer pathway discovery in this context. We applied our bipartite graph-based functional module discovery algorithm to identify transcriptomic modules abnormally expressed in multiple tumors, such that...

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Identifiers

PMID: 27758891
DOI: 10.1158/0008-5472.CAN-16-1740
PMCID: PMC5165695

Genes

MED1
PTK2
YWHAZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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