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Article

Functional synergies yet distinct modulators affected by genetic alterations in common human cancers.

Cancer research - 15 May 2011

Bessarabova Marina, Pustovalova Olga, Shi Weiwei, Serebriyskaya Tatiana, Ishkin Alex, Polyak Kornelia, Velculescu Victor E, Nikolskaya Tatiana, Nikolsky Yuri

Abstract excerpt

An important general concern in cancer research is how diverse genetic alterations and regulatory pathways can produce common signaling outcomes. In this study, we report the construction of cancer models that combine unique regulation and common signaling. We compared and functionally analyzed sets of genetic alterations, including somatic sequence mutations and copy number changes, in breast, colon, and...

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PMID: 21398405
DOI: 10.1158/0008-5472.CAN-10-3038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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