Article
Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes.
Cell reports - 21 Dec 2021
McMurray Helene R, Ambeskovic Aslihan, Newman Laurel A, Aldersley Jordan, Balakrishnan Vijaya, Smith Bradley, Stern Harry A, Land Hartmut, McCall Matthew N
Abstract excerpt
Malignant cell transformation and the underlying reprogramming of gene expression require the cooperation of multiple oncogenic mutations. This cooperation is reflected in the synergistic regulation of non-mutant downstream genes, so-called cooperation response genes (CRGs). CRGs affect diverse hallmark features of cancer cells and are not known to be functionally connected. However, they act as critical...
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