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Article

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets.

PLoS computational biology - 1 Aug 2015

Lu Songjian, Lu Kevin N, Cheng Shi-Yuan, Hu Bo, Ma Xiaojun, Nystrom Nicholas, Lu Xinghua

Abstract excerpt

An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit mutual exclusivity, in which these SGAs usually do not co-occur in a tumor. With some success, this characteristic has been...

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PMID: 26317392
DOI: 10.1371/journal.pcbi.1004257
PMCID: PMC4552843

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