Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.

Cell death & disease - 16 Jul 2015

Liu J, Bi X, Chen T, Zhang Q, Wang S-X, Chiu J-J, Liu G-S, Zhang Y, Bu P, Jiang F

Abstract excerpt

Disturbed cell autophagy is found in various cardiovascular disease conditions. Biomechanical stimuli induced by laminar blood flow have important protective actions against the development of various vascular diseases. However, the impacts and underlying mechanisms of shear stress on the autophagic process in vascular endothelial cells (ECs) are not entirely understood. Here we investigated the impacts of shear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy-Related Protein 5
Share to Forkhead Box Protein O1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Mechanotransduction, Cellular

Share to Sirtuin 1

Share to Stress, Mechanical

Share to TOR Serine-Threonine Kinases

Share to Ubiquitin-Activating Enzymes

Source

Open in PubMed Open full text

Identifiers

PMID: 26181207
DOI: 10.1038/cddis.2015.193
PMCID: PMC4650738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.PMID 26181207Read ↗

Shear Stress in Autophagy and Its Possible Mechanisms in the Process of AtherosclerosisSemantic proximity Read ↗

Shear Stress Induces Phenotypic Modulation of Vascular Smooth Muscle Cells via AMPK/mTOR/ULK1-Mediated Autophagy.Semantic proximity Read ↗

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosisSemantic proximity Read ↗

Laminar Shear Stress Increases the Cytosolic Pool of PINK1 in Endothelial Cells and Enhances Mitophagic Sensitivity Toward Dysfunctional MitochondriaSemantic proximity Read ↗

Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.Semantic proximity Read ↗

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions.Semantic proximity Read ↗

Autophagy in vascular endothelial cellsSemantic proximity Read ↗

Systems biology analysis of longitudinal functional response of endothelial cells to shear stressSemantic proximity Read ↗

Hemodynamic shear stress and its role in atherosclerosis.Semantic proximity Read ↗

Mechanotransduction of shear in the endothelium: Basic studies and clinical implicationsSemantic proximity Read ↗

Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis DevelopmentSemantic proximity Read ↗

Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.