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Article

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

Circulation research - 27 Feb 2009

Chen Zhen, Peng I-Chen, Sun Wei, Su Mei-I, Hsu Pang-Hung, Fu Yi, Zhu Yi, DeFea Kathryn, Pan Songqin, Tsai Ming-Daw, Shyy John Y-J

Abstract excerpt

Endothelial nitric oxide synthase (eNOS) plays a central role in maintaining cardiovascular homeostasis by controlling NO bioavailability. The activity of eNOS in vascular endothelial cells (ECs) largely depends on posttranslational modifications, including phosphorylation. Because the activity of AMP-activated protein kinase (AMPK) in ECs can be increased by multiple cardiovascular events, we studied the...

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Identifiers

PMID: 19131647
DOI: 10.1161/CIRCRESAHA.108.187567
PMCID: PMC2761102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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