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Article

MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells.

American journal of physiology. Heart and circulatory physiology - 15 Apr 2014

Weber Martina, Kim Sinae, Patterson Nicole, Rooney Kimberly, Searles Charles D

Abstract excerpt

Previously, we identified a microRNA (miRNA) signature for endothelial cells (ECs) subjected to unidirectional shear stress (USS). MiR-155, a multifunctional miRNA that has been implicated in atherosclerosis, was among the shear stress-responsive miRNAs. Here, we examined the role of miR-155 in modulating EC phenotype and function. In vitro, increased miR-155 levels in human ECs induced changes in morphology and...

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Identifiers

PMID: 24486510
DOI: 10.1152/ajpheart.00521.2013
PMCID: PMC3989748

Genes

MYLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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