Article
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.
Circulation research - 5 Feb 2010
Li Li, Rezvan Amir, Salerno John C, Husain Ahsan, Kwon Kihwan, Jo Hanjoong, Harrison David G, Chen Wei
Abstract excerpt
RATIONALE: GTP cyclohydrolase I (GTPCH-1) is the rate-limiting enzyme involved in de novo biosynthesis of tetrahydrobiopterin (BH(4)), an essential cofactor for NO synthases and aromatic amino acid hydroxylases. GTPCH-1 undergoes negative feedback regulation by its end-product BH(4) via interacti...
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